Bacillus velezensis 747

Spore-forming Probiotic Supports GI health and Immune Function

Bacillus velezensis 747 is a Gram-positive, spore-forming bacterium that has been recognized under the European Food Safety Authority’s Qualified Presumption of Safety (QPS) list. B. velezensis strain 747 was initially selected from the Arm & Hammer Research Library of probiotic strains due to its efficacy in controlling populations of pathogenic bacteria. Recent studies have further elucidated its role in promoting digestive health.

In vitro experiments have demonstrated that B. velezensis 747 exhibits resistance to low pH conditions (pH 1.5 and 3.0) and can survive in the presence of physiological concentrations of bile salts for extended durations. This indicates the probiotic’s potential to endure the gastrointestinal (GI) tract and reach the intestine effectively.

Subsequent in vitro assays have shown that B. velezensis 747 enhances barrier integrity, as evidenced by an increase in Transepithelial Electrical Resistance (TEER) in human intestinal epithelial Caco-2 cells. When these cells were stimulated with the inflammatory cytokine TNF-α for 24 hours—an agent known to increase intestinal permeability—B. velezensis 747 was able to reverse the TNF-α-induced loss of barrier function, restoring it to levels comparable to the untreated control epithelium. This suggests that the maintenance of an intact cellular lining of the intestinal wall, which is crucial for a healthy immune system, can be supported by B. velezensis 747.

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