Lactiplantibacillus plantarum 276
Supports Digestive and Immune Health
Lactiplantibacillus is a genus of Gram-positive, rod-shaped bacteria commonly found in fermented foods, plants, and the human gastrointestinal tract. Lactiplantibacillus plantarum, in particular, has a long history of safe consumption in humans and has been utilized in food processing and fermentation for generations.
A panel of Lactiplantibacillus strains from the Arm & Hammer microbial library was assessed for their ability to decrease inflammatory markers in response to lipopolysaccharide (LPS) stimulation. From this panel, a specific strain, L. plantarum 276 (Lp276), demonstrated superior anti-inflammatory characteristics in an intestinal epithelial cell inflammation model and has been developed for probiotic use in humans.
In vitro studies with L. plantarum 276 have shown that this strain is highly resistant to the acidic conditions of the stomach and can survive in the presence of bile acids at concentrations found in the intestine. Furthermore, L. plantarum 276 contains multiple fibronectin-binding genes, which are proteins expressed by the intestinal epithelium, as well as mucus-binding genes. The expression of these genes is a strong indicator of L. plantarum 276’s ability to adhere to intestinal tissues.
An intact intestinal barrier is the first line of defense in the immune system. In vitro studies measuring the Transepithelial Electrical Resistance (TEER) of human Caco-2 monolayers, a model of intestinal permeability, have demonstrated the ability of L. plantarum 276 to reverse the decreased intestinal barrier function induced by bacterial LPS. Further in vitro studies have shown that Lp276 can enhance wound repair in intestinal epithelial monolayers.
A randomized, double-blind, placebo-controlled, parallel pilot study with 50 participants was conducted to evaluate the effects of L. plantarum 276. The results indicated improvements in several indicators related to gastrointestinal health in the Lp276 group compared to the placebo group, including improved stool consistency, a reduction in the urgent need to use the bathroom, and enhanced quality of life standards.
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